Asiatic acid derivative, preparation method thereof, and applications of asiatic acid derivative in preparation of antidepressant drugs

作者: 栾洁 , 张术 , 陈松 , 储智勇 , 邹赢锌

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摘要: The invention provides an asiatic acid derivative compound represented by general formula (I), or a pharmaceutically acceptable salt ester thereof, any optical isomer of the compound, tautomer compound. also preparation method wherein is obtained via structural modification with microorganisms. applications above in antidepressant drugs. It shown mice forced swimming tests and tail suspension that possesses relatively high activity.

参考文章(1)
Wen-Zhi Yang, De-An Guo, Fei-Xia Huang, Xiong-Hao Lin, Wen-Ni He, Wei Song, Min Ye, Two new oxidation products obtained from the biotransformation of asiatic acid by the fungus Fusarium avenaceum AS 3.4594. Journal of Asian Natural Products Research. ,vol. 14, pp. 1039- 1045 ,(2012) , 10.1080/10286020.2012.702761