Two new oxidation products obtained from the biotransformation of asiatic acid by the fungus Fusarium avenaceum AS 3.4594.
作者： Wen-Zhi Yang , De-An Guo , Fei-Xia Huang , Xiong-Hao Lin , Wen-Ni He
DOI: 10.1080/10286020.2012.702761
关键词: Terpene 、 Fusarium 、 ASIATIC ACID 、 Organic chemistry 、 Fungus 、 Fusarium avenaceum 、 Triterpenoid 、 Biotransformation 、 Stereochemistry 、 Biology 、 Stereoisomerism
摘要: Asiatic acid (AA) is a natural triterpenoid possessing anti-inflammatory, anticancer, neuroprotective, and hepatoprotective activities. Structural modification of AA may provide valuable information for further structure-activity relationship analysis. Biotransformation an efficient, specific, environment friendly technology structural complicated products. In this study, the capabilities twenty-five strains filamentous fungi to transform were screened. Two new one known oxidation products metabolized by Fusarium avenaceum AS 3.4594 isolated. Their chemical structures characterized as 2-oxo-3β,15α,23-trihydroxyurs-12-en-28-oic (1), 3-oxo-2,15α,23-trihydroxyurs-1,12-dien-28-oic (2), 2-oxo-3β,23-dihydroxyurs-12-en-28-oic-acid (3) extensive analysis spectroscopic data.
core.ac.uk
sci-hub.se 参考文章(24)
Wen-Ni He, Jun-Gui Dai, Min Ye, Li-Jun Wu, De-An Guo, Microbial transformation of asiatic acid byAlternaria longipes Journal of Asian Natural Products Research. ,vol. 12, pp. 760- 764 ,(2010) , 10.1080/10286020.2010.501505
Kyung-Jin Yun, Ji-Yeon Kim, Jong-Bin Kim, Kyung-Won Lee, Seo-Young Jeong, Hee-Juhn Park, Hyun-Ju Jung, Young-Wuk Cho, Kijoo Yun, Kyung-Tae Lee, Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways International Immunopharmacology. ,vol. 8, pp. 431- 441 ,(2008) , 10.1016/J.INTIMP.2007.11.003
T.D. Babu, G. Kuttan, J. Padikkala, Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban Journal of Ethnopharmacology. ,vol. 48, pp. 53- 57 ,(1995) , 10.1016/0378-8741(95)01284-K
Kai Muffler, Doris Leipold, Marie-Christin Scheller, Christiane Haas, Juliane Steingroewer, Thomas Bley, H. Ekkehard Neuhaus, Marco Antonio Mirata, Jens Schrader, Roland Ulber, Biotransformation of triterpenes Process Biochemistry. ,vol. 46, pp. 1- 15 ,(2011) , 10.1016/J.PROCBIO.2010.07.015
Byung Chul Park, Kefa O. Bosire, Eung-Seok Lee, Yong Soo Lee, Jung-Ae Kim, Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells Cancer Letters. ,vol. 218, pp. 81- 90 ,(2005) , 10.1016/J.CANLET.2004.06.039
Byeong-Seon Jeong, Mi Kyeong Lee, Young Choong Kim, Eung-Seok Lee, Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects Archives of Pharmacal Research. ,vol. 30, pp. 282- 289 ,(2007) , 10.1007/BF02977607
Xiao-Chun Zheng, Sheng-Hao Wang, Determination of asiatic acid in beagle dog plasma after oral administration of Centella asiatica extract by precolumn derivatization RP-HPLC. Journal of Chromatography B. ,vol. 877, pp. 477- 481 ,(2009) , 10.1016/J.JCHROMB.2008.11.045
Jintanaporn Wattanathorn, Lugkana Mator, Supaporn Muchimapura, Terdthai Tongun, Orapin Pasuriwong, Nawanant Piyawatkul, Kwanchanok Yimtae, Bungorn Sripanidkulchai, Jintana Singkhoraard, Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. Journal of Ethnopharmacology. ,vol. 116, pp. 325- 332 ,(2008) , 10.1016/J.JEP.2007.11.038
M.H Veerendra Kumar, Y.K Gupta, Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats Journal of Ethnopharmacology. ,vol. 79, pp. 253- 260 ,(2002) , 10.1016/S0378-8741(01)00394-4
G. Jayashree, G. Kurup Muraleedhara, S. Sudarslal, V.B. Jacob, Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice Fitoterapia. ,vol. 74, pp. 431- 434 ,(2003) , 10.1016/S0367-326X(03)00121-7