Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects

作者: Byeong-Seon Jeong , Mi Kyeong Lee , Young Choong Kim , Eung-Seok Lee

DOI: 10.1007/BF02977607

关键词:

摘要: For the development of novel hepatoprotective agents, C2 functional group on asiatic acid was modified, and evaluated for their effects. Among prepared compounds, com-pounds10 and14 showed better effects compared to Silymarin.

参考文章(11)
F. Elsinger, J. Schreiber, A. Eschenmoser, Notiz über die Selektivität der Spaltung von Carbonsäuremethylestern mit Lithiumjodid Helvetica Chimica Acta. ,vol. 43, pp. 113- 118 ,(1960) , 10.1002/HLCA.19600430116
Hiroshi Hikino, Takatomi Ohsawa, Yoshinobu Kiso, Yoshiteru Oshima, Analgesic and antihepatotoxic actions of dianosides, triterpenoid saponins of Dianthus superbus var. longicalycinus herbs. Planta Medica. ,vol. 50, pp. 353- 355 ,(1984) , 10.1055/S-2007-969730
M. N. Berry, D. S. Friend, HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study Journal of Cell Biology. ,vol. 43, pp. 506- 520 ,(1969) , 10.1083/JCB.43.3.506
Liu Jie, Liu Yaping, Curtis D. Klaassen, The effect of Chinese hepatoprotective medicines on experimental liver injury in mice Journal of Ethnopharmacology. ,vol. 42, pp. 183- 191 ,(1994) , 10.1016/0378-8741(94)90084-1
B. Shukla, P. K. S. Visen, G. K. Patnaik, S. C. Tripathi, R. C. Srimal, R. Dayal, P. C. Dobhal, Hepatoprotective activity in the rat of ursolic acid isolated from eucalyptus hybrid Phytotherapy Research. ,vol. 6, pp. 74- 79 ,(1992) , 10.1002/PTR.2650060205
Yue Dai, Li-wu Tan, Bing-qian Hang, Pei-zheng Li, Effects of oleanolic acid on immune system and type I allergic reaction Acta Pharmacologica Sinica. ,vol. 10, pp. 381- 384 ,(1989)
Stanley Reitman, Sam Frankel, A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases American Journal of Clinical Pathology. ,vol. 28, pp. 56- 63 ,(1957) , 10.1093/AJCP/28.1.56
Rosemary Angel, Y. R. Chadha, The Wealth of India. Raw Materials Kew Bulletin. ,vol. 32, pp. 802- ,(1978) , 10.2307/4109779
Zhao Yc, Wang Ms, Han Dw, Yin L, Xu Rl, Ma Xh, Studies on the preventive and therapeutic effects of ursolic acid (UA) on acute hepatic injury in rats Acta pharmaceutica Sinica. ,vol. 21, pp. 332- ,(1986)
Tan Li-wu, Anti-inflammatory effect of oleanolic acid Chinese Journal of Pharmacology and Toxicology. ,(1989)