Evidence for supporting cell mitosis in response to acoustic trauma in the avian inner ear

摘要: Acoustic overstimulation can lead to sensory cell (hair cell) loss in the auditory epithelium. Damaged hair cells organ of Corti (the mammalian end-organ) degenerate and are replaced by non-sensory (supporting cells) which construct an irreversible scar. In birds, however, damaged acoustic trauma or ototoxic drugs may be new cells. As first step determining mechanism regeneration, we developed assay for divisions epithelium after trauma. The results these experiments demonstrate that supporting regions incorporate DNA-specific marker bromodeoxyuridine as early one day noise exposure. We provide direct evidence following insult avian inner ear, reside within divide near luminal surface repopulate These suggest participate scar formation during degeneration, produce regeneration.