Pulmonary hemodynamics and alveolar oxygenation in healthy dogs anesthetized with propofol or isoflurane during one-lung ventilation in a closed-thoracic experimental model.

摘要: OBJECTIVE To assess pulmonary hemodynamics and alveolar oxygenation in dogs anesthetized with propofol or isoflurane during one-lung ventilation (OLV) a closed-thoracic experimental model. ANIMALS 6 healthy Beagles. PROCEDURES Dogs were each of 3 protocols (constant rate IV infusion [0.4 to 1.0 mg/kg/min], at the minimum concentration [MAC], 1.5 MAC), 7-day washout period between anesthetic sessions. During session, intubated double-lumen endotracheal tube, positioned right lateral recumbency, administered atracurium (0.1 0.2 mg/kg, IV, q 30 min) allow mechanical throughout 2-hour observation period. underwent two-lung for minutes, OLV lung 1 hour, another minutes. Pulmonary hemodynamic blood gas variables evaluated predetermined times compared among over time within protocol. RESULTS Alveolar was not impaired, mean heart artery pressure occlusion similar protocols. One-lung caused significant increase arteriovenous shunt fraction only when MAC. developed respiratory acidosis, which exacerbated by OLV, all CONCLUSIONS AND CLINICAL RELEVANCE Results indicated model regardless whether isoflurane. can be successfully performed use tube either