The effects of increasing concentrations of isoflurane and desflurane on pulmonary perfusion and systemic oxygenation during one-lung ventilation in pigs.

摘要: UNLABELLED During one-lung ventilation (OLV), hypoxic pulmonary vasoconstriction (HPV) reduces venous admixture and attenuates the decrease in arterial oxygen tension by diverting blood from nonventilated lung to ventilated lung. In vitro, desflurane isoflurane depress HPV a dose-dependent manner. Accordingly, we studied effects of increasing concentrations on perfusion, shunt fraction, PaO(2) during OLV vivo. Fourteen pigs (30-42 kg) were anesthetized, tracheally intubated, mechanically ventilated. After placement femoral thermodilution artery catheters, left-sided double-lumen tube (DLT) was placed via tracheotomy. DLT placement, FIO(2) adjusted at 0.8 anesthesia continued random order with 3 (0.5, 1.0, 1.5 minimal alveolar concentrations) either or isoflurane. Differential perfusion measured colored microspheres. All measurements made after stabilization each concentration. Whereas mixed PO(2), mean pressure, cardiac output, fraction decreased manner, remained unchanged OLV. conclusion, concentration did not impair oxygenation pigs. IMPLICATIONS an animal model ventilation, dose-dependently oxygenation. The decreases are likely result anesthetic-induced marked output saturation.