The Effects of Intravenous Hyperoxygenated Solution Infusion on Systemic Oxygenation and Intrapulmonary Shunt During One-Lung Ventilation in Pigs

摘要: Background Many anesthetic methods have been applied to maintain acceptable oxygenation during one-lung ventilation (OLV). However, the optimal management has not definitely determined. The aim of this study was investigate whether intravenous hyperoxygenated solution (HOS) infusion would improve systemic and reduce intrapulmonary shunt OLV. Materials Sixteen pigs (25–35 kg) were anesthetized, tracheally intubated, mechanically ventilated. After placement femoral artery pulmonary catheters, a left-sided double-lumen tube (DLT) placed via tracheotomy. animals allocated randomly one two groups ( n = 8 each); control group (C group) (H group). Animals in H received HOS immediately after beginning OLV internal right jugular vein with an pump, rate 15 mL·kg −l ·h ; C group, same amount lactate Ringer's (LRS) used place HOS. Arterial venous blood gases analysis recorded three phases: two-lung just before (TLV), 30 min (OLV + 30), 60 60). We measured arterial oxygen saturation (SaO 2 ), mixing (S V O partial pressure (PaO (PvO 2), contents mixed (CaO , CvO admixture percentage (Qs/Qt%). Heart (HR), mean (MAP), (MPAP), cardiac output (CO) also recorded. Results OLV, there significant decrease PaO SaO PvO SvO CaO increase Qs/Qt% both P at significantly higher than those 60, no differences. Comparing values between Conclusions Intravenous led minimal changes shunt, nevertheless, it could ameliorate obviously This might be new strategy