Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and β-catenin expression

摘要: Aims The stage-dependent organization of the cardiomyocytes during formation different layers developing ventricular wall is critical for establishment a functional heart, but instructive signals involved are still poorly known. We have addressed potential role Wnt-11 in control early myocardium assembly. Methods and results demonstrate by means expression analysis mouse model which function has been inactivated that expressed embryonic serves as one important signal development. In absence Wnt-11, coordinated organization, intercellular contacts, co-localized cell adhesion components N-cadherin β-catenin, cytoskeleton differentiating all disturbed. Moreover, lacking signalling thinner Gata-4 , Nkx2.5 Mef2c ANP BNP genes down-regulated relative to controls. These defects lie behind disturbed cardiac development, marked an increase relaxation time diastole. Conclusion conclude cue wall, essential heart.