Detection of human herpesvirus 6 variant A in peripheral blood mononuclear cells from multiple sclerosis patients.

摘要: Several authors report that human herpesvirus 6 (HHV-6) variants have different epidemiologies, in vivo tropism and pathogenic potentials. However, it is not well known what roles its neurotropism might the variant type. As some active plaques of multiple sclerosis (MS) brain tissue harbor HHV-6 DNA divergent from prototype virus, possibility strain may play a role pathogenesis MS has been suggested. Therefore, we tried to investigate MS. predominantly T-cell-tropic examined sequences peripheral blood mononuclear cells (PBMC) 34 patients, with idiopathic transverse myelitis, 2 optic neuritis 20 healthy controls. Nested polymerase chain reaction was used detect genome. To discern A B, amplification products were digested by restriction enzyme. We found 7 patients myelitis had On contrary, there no genome control group. All genomic (HHV-6A). Our results suggest detection HHV-6A PBMC raise relationship between latent infection