HHV-6 and the Central Nervous System

摘要: Publisher Summary This chapter focuses on evidence suggesting an association of human herpesvirus-6 (HHV-6) with four major disorders the central nervous system (CNS): childhood febrile seizures, mesial temporal-lobe epilepsy (MTLE), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Detection HHV-6 genome in brain per se does not necessarily indicate productive infection, establishing a primary pathogenic role for CNSdisorders is challenging. Nevertheless, has been associated aseptic meningoencephalitis, encephalitis, transverse myelitis, Guilain-Barre´ syndrome, cerebellar astrocytoma. Although HHV-6A variant increased neurotropism viral persistence reactivation CNS, both variants are clearly neurotropic. isolated from CNS acquired immuno deficiency syndrome (AIDS) patients areas demyelination MS. MS most prevalent demyelinating disease CNS. The variability diseases suggests that many factors, including genetic immune components, involved spectrum clinical syndromes defined as HHV-6B causative agent exanthem subitum accounts majority symptomatic infections infants.