Dietary fatty acids and myocardial function

摘要: It is widely recognized that dietary polyunsaturated fatty acids (PUFA’s) and cholesterol can profoundly influence the development of atherosclerotic plaques in coronary vessels, which may lead to myocardial infarction. The possibility also directly cardiac function has received less attention. We therefore reviewed evidence effects acids, particular n-3 n-6 PUFA’s, on phospholipid acid composition cardiovascular performance. Heart organelles appear incorporate uncommon like 22:1 trans- 18:1. Diets enriched with induce lipidosis. N-9, families compete among membrane C20 C22 acids. Several studies have dealt relation between diet-induced changes (sarcolemma, sarcoplasmic reticulum mitochondria) phospholipids function. In view variety diets used functions studied, results do not permit equivocal interpretation. investigators reported an altered stress response heart due a change PUFA’s diet. rats fed low 18:2n-6/18:3n-3 ratio combined relatively amounts saturated high incidence lesions been observed. Pigs are sensitive but more susceptible vitamin E deficiency, when PUFA content high. Increased contractility flow rate for Langendorff-perfused hearts 18:2n-6-rich diets. possibly related alterations eicosanoid synthesis, contribute reduction by or infarct size, magnitude recovery suppression reperfusion arrhythmias following release artery ligation. On other hand, increased peroxidation lipids, their PUFA, be deleterious.