The Dectin-2 family of C-type lectins in immunity and homeostasis.

摘要: C-type lectins are a diverse family of proteins which recognize wide range ligands. This review focuses on the Dectin-2 that includes Dectin-2, BDCA-2, DCIR, DCAR, Clecsf8 and Mincle whose genes clustered in telomeric region NK-gene cluster mouse chromosome 6 human 12. These type II receptors expressed myeloid non-myeloid cells contain single extracellular carbohydrate recognition domain have functions both immunity homeostasis. DCIR is only member contains cytoplasmic signalling motif has been shown to act as an inhibitory receptor, while DCAR all associate with FcRγ chain induce cellular activation, including phagocytosis cytokine production. pattern for fungi, acts attachment factor HIV. In addition pathogen recognition, be pivotal preventing autoimmune disease by controlling dendritic cell proliferation, whereas recognizes nuclear protein released necrotic cells. Here we each these detail describing their expression, ligand known physiological functions.