LATE COMPLICATIONS OF PELVIC IRRADIATION IN 16 DOGS

摘要: When external beam radiation therapy is administered to the pelvis, normal tissues irradiated may include colon, small intestine, urethra, bladder, bone, and spinal cord. The objectives of this retrospective study were determine incidence severity late effects following pelvic irradiation in dogs identify factors that increase risk these effects. Medical records all treated with curative intent region between 1993 1999 reviewed. Patients follow-up longer than 9 months or any patient developed complications earlier evaluated. Sixteen met criteria for inclusion study. All a 6-MV linear accelerator bilaterally opposed beams. Diseases included transitional cell carcinoma prostate, anal sac apocrine gland adenocarcinoma. Four dose/fractionation schemes used: 49.5 Gy 3.3 fractions, 54 3.0 2.7 18 intraoperative followed by 43 2.9 fractions. Implantable chemotherapy form an OPLA-Pt sponge was used six as potentiator. Colitis major effect irradiation, occurring nine (56%). characterized mild three dogs, moderate one dog, severe five dogs. Three suffered gastrointestinal perforation. received 3 per fraction, 80% potentiators. In seven classified none (n = 5), colitis 1), 1). Radiation can be minimal colon giving smaller doses fraction avoiding systemic