Early and late damage in the mouse bladder after radiation combined with cyclophosphamide or cisplatinum, evaluated by two different functional assays.

摘要: Early and late changes in the reservoir function of mouse bladder were investigated after irradiation alone or combined with cisplatinum (cis-DDP) cyclophosphamide (CTX). Bladder was repeatedly assessed from independent assays urination frequency cystometry. Treatments consisted 10-30 Gy x-rays 10-22.5 chemotherapy (cis-DDP 6 mg/kg i.p. CTX 100 i.p.). Within 30 days treatment, early damage detected by both but correlation between significant only group treated CTX. The response irreversible a found (p < 0.05) results cystometry assay all treatment groups. After plus cis-DDP, RD50 values (the radiation dose that induced 50% animals) decreased time as occurred. CTX, maximum appeared much earlier tended to increase 12 40 weeks. Comparison these gave dose-effect factor ratio doses for x-ray drug) 1.1 1.3 cis-DDP assays. enhancing effect on greater, especially assay, indicated considerably lower values. This resulted an estimated up 2.4. In conclusion, are suitable investigating damage, although functional defect measured is different. Both increased when irradiation. Late groups than mice alone.