Late changes in the normal mouse bladder after irradiation alone or in combination with cis-DDP or cyclophosphamide, assessed by stereological analysis

摘要: Stereological analysis has been performed to investigate the late changes in normal mouse bladder one year after radiation alone (10-25 Gy) or (10-15 combined with cyclophosphamide (CTX), 100 mg/kg, cis-diamminedichloroplatinum (II) (cis-DDP), 6 mg/kg. A significant increase total volume of urothelium was found group treated CTX compared control. The connective tissue muscular layer groups which received X-rays only showed a There also seemed be an amount tissue, although this not statistically significant, and irradiation alone. This indicates importance development damage. Results from bladders cis-DDP were inconclusive due small number animals each group. (15 decrease lamina propria, but no difference other treatment when comparing vessels capillaries their corresponding control groups. seems feasible method demonstrate encountered chemotherapy.