作者: Shiro Suetsugu , Alexis Gautreau
DOI: 10.1016/J.TCB.2012.01.001
关键词:
摘要: Cell and organelle shape can profoundly influence proper cellular function. In recent years, two machineries have emerged as major regulators of membrane shape: Bin-Amphiphysin-Rvs161/167 (BAR) domain-containing proteins, which induce invaginations or protrusions, nucleation promoting factors (NPFs), activate the Arp2/3 complex are thus responsible for generation branched actin networks that push on membranes. Several BAR–NPF interactions been shown to various types such lamellipodia filopodia, invaginations, including trafficking organelles caveolae, endosomes clathrin-coated pits (CCPs). This review focuses how collaboration between these interacting machineries, emerges a unified mechanism remodeling, accounts variety shapes.