Early Life Conditions and Later Life Mortality

摘要: Although the idea that early life conditions shape mortality is not new, there has been a resurgence of studies on topic in last two decades. In our review this work, we weigh evidence for major causal mechanisms, i.e., biological imprint and pathway processes, thought to underlie associations between childhood adult mortality. We also examine how key social physical exposures are associated with through these mechanisms. Drawing Health Retirement Study, then offer additional While results reinforce importance understanding mortality, they, as well previous literature, highlight conceptual analytical challenges. Associations mechanisms sensitive, example, particular exposures, period manifestation, type health problem. Nonetheless, body strongly points having an enduring influence both processes. argue variability should be expected historically within populations, reflects sociohistorical differences life-course exposures.