Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan
作者： Christine Y. Chuang , Megan S. Lord , James Melrose , Martin D. Rees , Sarah M. Knox
DOI: 10.1021/BI1005199
关键词:
摘要: Perlecan is a large multidomain proteoglycan that essential for normal cartilage development. In this study, perlecan was localized in the pericellular matrix of hypertrophic chondrocytes developing human rudiments. immunopurified from medium conditioned by cultured fetal found to be substituted with heparan sulfate (HS), chondroitin (CS), and keratan (KS). Ligand carbohydrate engagement (LACE) assays demonstrated chondrocyte-derived formed HS-dependent ternary complexes fibroblast growth factor (FGF) 2 either FGF receptors (FGFRs) 1 or 3; however, these were not biologically active BaF32 cell system. Chondrocyte-derived also FGF18 FGFR3. The proliferation cells expressing FGFR3 promoted presence FGF18, activity reduced digestion HS heparina...
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