Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder

摘要: Background The autotaxin/lysophosphatidic acid axis is involved in diverse biological processes including neurodevelopment, inflammation, and immunological functioning. lysophosphatidic 1 receptor has been implicated the pathophysiology of major depressive disorder mechanism action antidepressants. However, it unclear whether central or peripheral autotaxin levels are altered patients with disorder. Methods Serum were measured by an enzyme-linked immunosorbent assay 37 diagnosed using DSM-IV-TR who underwent electroconvulsive therapy compared those 47 nondepressed controls matched for age sex between January 2011 December 2015. Patient serum before after also compared. In a separate sample set, cerebrospinal fluid 26 27 2010 A potential association was examined clinical symptoms assessed Hamilton Depression Rating Scale. Results Before therapy, both fluidautotaxin significantly lower than (serum: P = .001, fluid: .038). negative correlation serum, but not fluid, observed (P .032). After parallel increase improvement .005). Conclusion current results suggest that reduced state-dependent manner. reduction suggests dysfunction brains