Interleukin-25: A Key Initiator of Type 2 Immune Responses

作者: Hiroshi Nakajima , Tomohiro Tamachi , Koichi Hirose

DOI: 10.1007/978-4-431-54442-5_10

关键词:

摘要: T helper 2 (Th2) cells induce allergic inflammation through the production of Th2 cytokines such as interleukin (IL)-4, IL-5, and IL-13. In addition, it has been demonstrated that IL-25 (IL-17E) is involved in initiation amplification type immune responses. Recent studies have shown a number cell types including activated cells, epithelial mast eosinophils, macrophages produce response to variety stimuli. Regarding IL-25-responding accumulating evidence revealed induces responses activation natural killer (NKT) innate multipotent progenitor (MPPtype2) (NH cells), nuocytes, (Ih2) myeloid (T2M) cells. vivo, we others expressed airways murine asthma models induction antigen-induced airway remodeling. humans, suggested be pathogenesis diseases Churg–Strauss syndrome. this chapter, summarize recent advances regarding biology IL-25.

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