Pharmacogenetics of coumarin anticoagulants in Brazilians.
作者： Guilherme Suarez-Kurtz , Mariana R Botton
DOI: 10.1517/17425255.2015.976201
关键词:
摘要: Introduction: Coumarin vitamin K antagonists are the mainstay of anticoagulant therapy in atrial fibrillation, prosthetic heart valves and thromboembolic conditions. Concerns with these drugs include large inter-individual variability dose requirements, narrow therapeutic index need to monitor prothrombin time repeatedly.Areas covered: Pharmacogenetic studies dosing algorithms for warfarin phenprocoumon.Expert opinion: Gene candidate Brazilian patients verified consistently association pheprocoumon stable requirements CYP2C9 VKORC1 polymorphisms, minor or no influence other pharmacogenes (e.g., CYP4F2 F7). The predictive power phenprocoumon developed Brazilians compares favorably those reported populations. A algorithm derived an admixed cohort performed equally well self-reported White Black patients, marked contrast considerably poorer perform...
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