Error-Prone Repair of DNA Double-Strand Breaks.

摘要: Preserving the integrity of DNA double helix is crucial for maintenance genomic stability. Therefore, double-strand breaks represent a serious threat to cells. In this review, we describe two major strategies used repair strand breaks: non-homologous end joining and homologous recombination, emphasizing mutagenic aspects each. We focus on emerging evidence that long thought be an error-free process, can in fact highly mutagenic, particularly contexts requiring large amounts synthesis. Recent investigations have begun illuminate molecular mechanisms by which error-prone break create changes, such as translocations complex chromosome rearrangements. highlight these studies discuss proposed models may explain some more extreme genetic changes observed human cancers congenital disorders. J. Cell. Physiol. 230: 15–24, 2016. © 2015 Wiley Periodicals, Inc.