Short chain fatty acids inhibit the expression of the neutrophil chemoattractant, interleukin 8, in the Caco-2 intestinal cell line.

摘要: The histologic appearance of active ulcerative colitis includes an intense lymphoplasmocytosis limited to the mucosa and submucosa often notable for a neutrophilic infiltrate invading colonic epithelium (crypt abscess). Multiple investigators have shown that is in hyperproliferative state with expansion proliferative compartment from lower crypt upper extending surface (1,2). This independent degree inflammation duration disease exists even when quiescent Similar states been observed patients at risk malignancy such as familial polyposis coli, sporadic colon adenomas, nonpolyposis cancer (3). An intriguing observation made by Scheppach et al. (4) labeling index colonocytes fell normal healthy controls after treatment butyrate enemas. suggests may fundamentally alter proliferation, perhaps differentiation, epithelial cells colitis.