CHAPTER 47 – Peripheral Neuropathy

摘要: Publisher Summary This chapter discusses autoimmunity implicated in peripheral nerve diseases. These include the acute inflammatory neuropathies eponymously referred to as Guillain-Barre (GBS) and Fisher syndromes (FS), chronic demyelinating polyradiculoneuropathies (CIDP), both idiopathic associated with a serum paraprotein. The diagnosis of GBS remains clinical, but electrophysiologic studies help subtype patients into diagnostic categories. Some these polyradiculoneuropathy (AIDP), motor axonal neuropathy (AMAN), sensory (AMSAN), syndrome. Furthermore, molecular mimicry has been invoked mechanism variety autoimmune AMAN FS provide some best available evidence support hypothesis pathogenetic underlying postinfectious disorders. CIDP are heterogeneous clinical conditions which humoral cellular mechanisms conspire cause disabling Although there still innumerable advances be made, greater understanding pathomechanisms is inspiring trials novel agents for treatment.