Shiga toxin-converting phages and the emergence of new pathogenic Escherichia coli: a world in motion

摘要: Shiga toxin (Stx)-producing Escherichia coli (STEC) are pathogenic E. causing diarrhea, hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). STEC characterized by a constellation of virulence factors additional to Stx have long been regarded as capable cause HC HUS when possessing the ability inducing attaching effacing (A/E) lesion enterocyte, although strains isolated from such severe infections sometimes lack this feature. Interestingly, capability A/E is shared with another pathogroup, Enteropathogenic (EPEC). In very recent times, different type broke scene shift in paradigm for HUS-associated STEC. 2011, O104:H4 caused large outbreak more than 800 50 deaths. Such strain presented adhesion determinants Enteroaggregative (EAggEC). We investigated possibility that, besides EAggEC, other could be susceptible infection stx-phages. A panel stx2-phages obtained human disease was used infect experimentally representing all known types, including both diarrheagenic (DEC) extra-intestinal (ExPEC). observed that pathogroups experiments were infection. Our results suggest may not specificity adapted intestinal environment, at least conditions used. Additionally, we only observe transient lysogens suggesting event stable stx2-phage acquisition occurs rarely.