Sleep mechanisms: biology and control of REM sleep.

摘要: Publisher Summary Sleep is an extremely complex phenomenon involving all levels of the neuraxis and multiple regulation. This chapter summarizes evidence showing that a wide variety physiological systems normally exhibit concurrent changes in activity at transition between sleep waking states. The discusses biological aspects sleep, analysis brain-stem mechanisms with particular reference to rapid-eye-movement (REM) presents mechanistic model REM seeks explain some influences on this state. Studies have shown REM, sensitive temperature probably other metabolic modulated by circadian ultradian rhythms, particularly related increased protein synthesis. At level, several neuronal appear control components been identified, but no system accounts for state as unified entity. suggests critical mechanism must involve coupling may be mediated receptor