Vaccination Against Dengue: Challenges and Current Developments

摘要: Dengue is a growing threat worldwide, and the development of vaccine public health priority. The completion active phase two pivotal efficacy studies conducted in Asia Latin America by Sanofi Pasteur has constituted an important step. Several other approaches are under development, whichever technology used, developers face several challenges linked to particular nature etiology dengue disease. We start our review defining questions potential issues pathology presenting main types that have explored these questions; some candidates late stage clinical development. In second part review, we focus on candidate, describing steps from research III studies. Finally, discuss what could be next steps, before after introduction, ensure will provide best benefit with acceptable safety profile identified target populations.