Combination of gyrase b inhibitors and protein synthesis inhibitors and uses thereof

作者: Thomas Frank Dekoning , Donald Herman Batts

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摘要: The present invention relates to compounds and methods of treating, preventing, or lessening the severity drug-resistant Gram-positive bacterial infections in mammals. consist a combination gyrase B inhibitor protein synthesis inhibitor. These demonstrate antibacterial activity against strains bacteria, particular, methicillin-resistant Staphylococcus aureus (MRSA). Methods for inhibiting bacteria treating infection caused by such organisms are described herein.

参考文章(4)
Henry Fuchs, Francesco Parenti, Timothy Leach, Methods for treating and preventing Gram-positive bacteremias ,(2003)
Iain B Gosbell, Methicillin-Resistant Staphylococcus Aureus American Journal of Clinical Dermatology. ,vol. 5, pp. 239- 259 ,(2004) , 10.2165/00128071-200405040-00004