Ovarian cancer: natural history and metastatic pattern.

摘要: Ovarian cancer begins at a molecular level, however to date, our knowledge of genetic changes and mechanisms ovarian tumorigenesis is limited. The natural history may depend on different anatomo-clinical biological factors. In the life cancers stage, histology, tumor grade, age patient gene abnormalities, both oncogenes (c-myc, H-ra, new) oncosuppressor genes (p53, in particular), DNA ploidy steroid receptor status have important prognostic significance. Residual disease, when less than 1 cm, another factor, being significantly associated survival and, progression free, improvement survival. low stage (Stage IA, IB, IAII,IBII,IC,IIA,IIB,IIC), adjuvant treatment seems not influence Disease Free Survival (DFS) or Overall (OS) exception this rule cisplatin regimen assessed, as it can highly reduce relapse rate while influenced. disseminate, primarily by continuity. Lymphatic dissemination pelvic para-aortic lymph nodes (40% patients III-IV disease) well peritoneum common. At time diagnosis, bone brain metastases are rarely present their presence related histology grading tumor.