Fighting Insomnia and Battling Lethargy: The Yin and Yang of Palliative Care

摘要: There is an interdependent relationship between insomnia and fatigue in the medical literature, but both remain distinct entities. Insomnia entails problematic sleep initiation, maintenance, or restoration with accompanying decrease perceived daytime function. Lethargy a symptom that has wide differential diagnosis heavily overlaps cancer-related fatigue; however, may contribute to worsened lethargy cancer patients. major risk factor for mood disturbances such as depression, which also this at-risk population. The pathophysiology of discussed review, including their diagnoses well emerging understanding roles neurotransmitters, branched-chain amino acids, inflammatory cytokines. Treatment approaches are reviewed, role hypnotics, psychotropics, hormonal agents, alternative therapies.