Patient-reported sleep disturbance in advanced cancer: frequency, predictors and screening performance of the Edmonton Symptom Assessment System sleep item

摘要: Aims Sleep Disturbance (SD) is a severe debilitating symptom in advanced cancer patients (ACP). However, routine screening of SD uncommon. The primary aim this study was to determine the optimal cutoff score for Edmonton Symptom Assessment system (ESAS) sleep item using Pittsburgh Quality Index (PSQI) as gold standard. We also determined frequency SD, obstructive apnea symptoms (OSA) and restless leg syndrome (RLS) factors associated with SD. Methods prospectively surveyed 180 consecutive ACP. Patients completed validated assessment symptoms. epidemiological performance, receiver operating characteristics, correlations Results according PSQI diagnosed 112/180 (62%), median (IQR) ESAS 5 (2-7). ≥ 4 had sensitivity 74% 80%, specificity 71% 64% training validation samples, respectively OSA 61%; RLS 38%. [r, p-value] (0.61, Conclusions frequent has good screening.