Lead and other trace metals in preeclampsia: A case–control study in Tehran, Iran

摘要: To assess the effects of environmental exposures to trace metals on incidence preeclampsia, concentrations lead (Pb), antimony (Sb), manganese (Mn), mercury, cadmium, cobalt and zinc in umbilical cord blood (UCB) mother whole (MWB) were measured 396 postpartum women without occupational exposure Tehran, Iran, using inductively coupled plasma mass spectrometry. Mother's ages ranged from 15 49 (mean 27) years. Preeclampsia was diagnosed 31 subjects (7.8%). Levels Pb, Sb Mn UCB significantly higher preeclampsia cases [mean+/-SD 4.30+/-2.49 microg/dl, 4.16+/-2.73 46.87+/-15.03 microg/l, respectively] than controls [3.52+/-2.09 3.17+/-2.68 40.32+/-15.19 (P<0.05). The logistic regression analysis revealed that one unit increase common logarithms concentration or led risk several-fold; risks (95% CI) 12.96 (1.57-107.03), 6.11 (1.11-33.53) 34.2 (1.81-648.04) for Mn, respectively These findings suggest may exposure; levels be sensitive indicators female reproductive toxicity as compared with those MWB. Further studies are necessary confirm these findings, especially Mn.