Cardiac effects of sodium stibogluconate: myocardial, electrophysiological and biochemical studies

摘要: The pentavalent antimonial sodium stibogluconate is the mainstay of anti-leishmanial therapy. Sodium less cardiotoxic than antimony and trivalent derivatives, but has been associated with dose-related electrocardiographic changes. effect currently-used regimen (20 mg/kg/day for 20 days) on cardiac function uncertain. We studied 12 soldiers, mean age 24 years, proven cutaneous leishmaniasis treated this regimen. There were no significant changes in echocardiographic indices left ventricular systolic or diastolic during treatment. Indices myocardial electrical stability (heart-rate variability episodes overt supraventricular arrhythmias) unchanged, there was a reversible decrease T-wave amplitude Systolic blood pressure fell heart rate increased This does not measurably impair function. Minor occur treatment, increase arrhythmia frequency change heart-rate variability. In most young fit patients, side-effects. However, idiosyncratic reactions cannot be excluded, patients malnutrition, impaired renal pre-existing disease may more sensitive to any properties stibogluconate.