Relationship and significance of greatest percentage of tumor and perineural invasion on needle biopsy in prostatic adenocarcinoma.

摘要: Serum prostate-specific antigen (PSA) levels and the biopsy Gleason sum are used along with clinical staging to predict prostatectomy pathology results for men localized prostate cancer. The additional predictive value of perineural invasion (PNI) in pretreatment needle biopsies evaluating tumor stage this setting is controversial. current study evaluates independent PNI a cohort 632 who underwent radical retropubic prostatectomies clinically adenocarcinoma between years 1994 1998. None these received hormonal or radiation therapy before surgery. In addition sum, contained detailed information regarding burden: 1) total number cores involved by adenocarcinoma, 2) greatest percentage any single carcinoma (GPC), 3) cancer added over all (TPC). presence absence was recorded. Pretreatment factors were analyzed univariate multivariate fashion determine their using TNM (pT2 vs pT3) modified system, which includes surgical margin status pT3 positive margin) as end points. Univariate analysis revealed significant association disease several preoperative including age, serum PSA, digital rectal examination, PNI, GPC, TPC, (p <0.01). Multivariate indicated that GPC contributed significantly predicting odds ratios 2.7 (95% CI, 1.7-4.3), 2.3 1.7-3.1), 1.7 1.1-2.7), 1.4-2.1) respectively. only when TPC not considered, due interaction <0.0001, Wilcoxon's rank test). These showed similar relationship adverse an alternative definition included margins (pT3 margin). more than disease. However, defined broadly margin.