Prediction of extraprostatic extension in the neurovascular bundle based on prostate needle biopsy pathology, serum prostate specific antigen and digital rectal examination.

摘要: ABSTRACT Purpose: There are few studies on predictors of extraprostatic extension (EPE) in the region neurovascular bundle (NVB). We investigated whether clinical information and prostate biopsy data could predict EPE localized cancer. Materials Methods: Through a retrospective analysis pathology database we identified 2,660 cases clinically cancer treated with radical retropubic prostatectomy without preoperative adjuvant therapy at The Johns Hopkins Hospital. study sample involved total 3,006 lobes including 2,070 organ confined disease, 620 NVB posterolateral edge 316 other than (EPE elsewhere). univariate multivariate logistic regression determined patient age, year surgery, serum specific antigen, digital rectal examination, highest Gleason score, perineural invasion, percent side cores cancer, each core maximum was predictive NVB. Results: Prostate antigen (10 or greater vs less 10), score (7 6 less), examination (abnormal normal), tumor (greater 33.3% less) average involvement positive 20% were all found to be statistically significant independent penetration analysis. generated model stratifies these variables into high low risk. probability 10% 1 fewer higher risk more variables. Conclusions: this allows for identification patients Our algorithm will help provide objective parameters that aid decision spare safely.