DRUG-INDUCED ARTHROPATHY AND NECROSIS OF THE FEMORAL HEAD

摘要: 1. It is well known that the administration of corticosteroids may result in necrosis and progressive destruction femoral head. Identical changes have been found chronic alcoholics, South African negroes suffering from iron-overload osteoporosis patients with arthritis hip treated non-steroid anti-inflammatory analgesic preparations. The term "drug-induced arthropathy" used to describe common pathological lesion. 2. Seventy-two this complication investigated forty-two heads were available for detailed study. characteristic change subchondral fragmentation osteonecrosis, followed later by reactive bone formation typical increased radiographic density. 3. frequent occurrence fat occupying Haversian canals affected has not adequately explained its relationship destructive arthropathy remains obscure. findings presented here do support theory emboli are responsible changes. 4. More credence given microfracture osteoporotic bone. invariably follows some or preparation. postulated a state diminished sensibility predisposes microtrauma resulting subarticular collapse