White matter hyperintensities associated with small vessel disease impair social cognition beside attention and memory.

摘要: Age-related white matter hyperintensities (WMH) are a manifestation of damage seen on magnetic resonance imaging (MRI). They related to vascular risk factors and cognitive impairment. This study investigated the profile at different stages WMH in large community-dwelling sample; 849 subjects aged 21 79 years were classified 4-stage Fazekas scale according hyperintense lesions individual T2-weighted fluid-attenuated inversion recovery MRI scans. The evaluation functioning included seven domains performance five subjective impairment, as proposed by DSM-5. For first time, impact age-related Theory Mind was investigated. Differences between groups analyzed non-parametrically effect sizes computed. Effect revealed slight overall decline 1 2 relative healthy subjects. group 3 presented substantial social cognition, attention memory, although characterized high inter-individual variability. reported decline. We demonstrate that extensive associated with specific impairment attention, performance. detailed neuropsychological characterization offers new therapeutic possibilities for those affected