Expression of the retinoblastoma gene product in bladder carcinoma cells associates with a low frequency of tumor formation.

摘要: Upon inactivation of both alleles the retinoblastoma gene (RB), individuals develop intraocular eye tumor, retinoblastoma. The encodes a M r 110,000 phosphorylated nuclear protein that may be involved in regulation cell cycle. Besides mutations have been detected several other types tumors, including bladder carcinoma. Up to one-third carcinomas contain RB gene. Introducing into single retinoblastoma, osteosarcoma, or prostate carcinoma lines suppresses their tumorigenicity as assayed nude mice