Caffeate derivatives induce apoptosis in COLO 205 human colorectal carcinoma cells through Fas- and mitochondria-mediated pathways
作者： Dev-Aur Chou , Yueh-Hsiung Kuo , Ming-Shiou Jan , Yuan-Yen Chang , Yi-Chen Chen
DOI: 10.1016/J.FOODCHEM.2011.10.027
关键词:
摘要: Abstract The objective of this study was to investigate the anticancer activity caffeate derivatives in human cancer cells. Our results demonstrate that decreased population growth COLO 205, assessed using MTT assay. However, derivatives, at concentrations used (0–250 μM) did not affect viability HepG2, Huh7, PLC5, and SK-Hep-1 Flow cytometric analysis 205 cells exposed decyl showed number apoptotic increased a time- dose-dependent manner. Western blot revealed stimulated an increase protein expression levels p53, Fas, FasL, AIF, Apaf-1. Additionally, treatment with changed Bcl-2 family members subsequently induced activation caspase-12, caspase-9, caspase-3, which followed by cleavage PARP. findings highlight chemopreventive potential caffeate.
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