Combined effects of eptifibatide and anticoagulants: differences between LMWH and UH or rH in thrombin generation inhibition but not in platelet aggregation inhibition.

摘要: Aim of our study was to investigate effects eptifibatide and anticoagulants on platelet aggregation thrombin generation under low high coagulant challenge in tissue factor-activated rich plasma using a model allowing simultaneous determination the time course generation. Eptifibatide exerted dose-dependent anti-aggregating effect both significantly stronger challenge. Combination resulted significant additive prolongation lag phase until onset aggregation, more pronounced Under high, but not combination had synergistic inhibitory aggregation. with LMWH, UH, or rH, reduced potential, F 1+2 generation, FXa formation compared measurements absence eptifibatide. We demonstrate inhibition an additional LMWH Our results support notion that might be beneficial atherosclerotic disease palliate thrombogenic potency ruptured plaques.