Effects of nadroparin, enoxaparin, and unfractionated heparin on endogenous factor Xa and IIa formation and on thrombelastometry profiles.
作者： Gerhard Cvirn , Thomas Wagner , Guenther Juergens , Martin Koestenberger
DOI: 10.1097/MBC.0B013E32831D0F80
关键词: Biochemistry 、 Pharmacology 、 Heparin 、 Enoxaparin sodium 、 Thrombin 、 Nadroparin calcium 、 Low molecular weight heparin 、 Anticoagulant 、 Whole blood 、 Chemistry 、 Nadroparin
摘要: Measurements of anti-FXa or anti-FIIa (thrombin) activities are conventional tests for biological monitoring low molecular weight heparin (LMWH) unfractionated treatment. It was the aim our study to assess anticoagulant efficacy LMWHs nadroparin and enoxaparin that not by above-mentioned isolated measurements but in physiological environment clotting plasma whole blood. The effects increasing amounts nadroparin, enoxaparin, on time-course FXa FIIa formation were investigated tissue factor activated platelet-poor using a subsampling technique chromogenic substrates. Moreover, these drugs also blood triggered relevant activator collagen/endogenous thrombin thrombelastometry. Nadroparin is as efficient concerning suppression endogenous formation. two capable suppressing FXa. Compared with equivalent activity, markedly more than LMWHs. Corresponding results obtained comparable influence thrombelastometry parameters stronger We conclude inhibitors only Under experimental conditions, lower heparin.
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