A perspective on the treatment of lyme borreliosis

摘要: Lyme borreliosis has become the most common tick-borne infection in United States. Although both beta-lactam and tetracycline antibiotics have been shown to be effective treatment of this spirochetosis, development optimal therapeutic modalities hampered by lack reliable microbiologic or immunologic criteria for diagnosis cure infection. In vitro sensitivity studies performed several laboratories, but there no standardization methodology measuring either inhibitory bactericidal levels. Clinical documented efficacy antibiotics, therapy failed as many 50% cases chronic new antibiotic regimens appear promising, infectious disease remains determined. report we review clinical experimental rationale that currently use need a more standardized approach trials.