Macrolide therapy of chronic Lyme Disease.

摘要: Background Macrolide antibiotics are highly active in vitro against B.burgdorferi, but have limited efficacy the treatment of patients with Lyme Disease. As macrolides less at a low pH, their poor clinical activity might be due to localization borrelia an acidic endosome, and improved by alkalinization that compartment hydroxychloroquine. Material/methods 235 multi-symptom complex typical chronic disease, ie fatigue, musculoskeletal pain, neurocognitive dysfunction serologic reactivity B.burgdorferi were treated macrolide antibiotic (eg clarithromycin) Results Eighty % had self-reported improvement 50% or more end 3 months. After 2 months treatment, 20% felt markedly (75-100% normal); after 45% improved. Improvement frequently did not begin until several weeks therapy. There no differences among three used. Patients who been on hydroxychloroquine alone experienced little improvement. Compared ill for than years, onset was slower, failure rate higher longer time periods. Conclusions These results support hypothesis reside endosome use lysosomotropic agent augments In contrast, tetracycline such is affected