Antibodies raised against β-adrenergic receptors stimulate adenylate cyclase
作者： Pierre-Olivier Couraud , Colette Delavier-Klutchko , Odile Durieu-Trautmann , A.Donny Strosberg
DOI: 10.1016/0006-291X(81)90760-9
关键词:
摘要: Abstract Antibodies raised in mice against β-adrenergic receptors purified from turkey erythrocyte membranes, specifically bind to cells which possess a receptor and immunoprecipitate radiolabelled receptor. These antibodies stimulate the adenylate cyclase activity of erythrocytes, although they do not compete with catecholamine hormones for binding Thus receptor-antibody interaction, occuring at another site than receptor-hormone may still trigger enzymatic activity.
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