Nucleotide Excision Repair (NER) and Role in Colorectal Carcinogenesis
作者： Aga Syed Sameer , Saniya Nissar
DOI: 10.1007/978-981-13-7197-4_7
关键词:
摘要: The bulky adduct lesions of DNA known to cause deleterious phenotypes in mammals, are mostly acted upon and removed from the genomic by nucleotide excision repair (NER) pathway. NER pathways with its TFIIH multi-protein complex containing an important helicase–xeroderma pigmentosum protein (XPD) serves as pivotal factor for identification opening up damaged lesion site so carry out process. In this chapter, we’ll be exploring new visions scientific research on functioning pathway, role central NER, helicase XPD lynchpin effects various single polymorphisms (SNPs) their consequent development progression colorectal cancer.
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