Activation of fibroblasts in cancer stroma.

摘要: Tumor microenvironment has emerged as an important target for cancer therapy. In particular, cancer-associated fibroblasts (CAF) seem to regulate many aspects of tumorigenesis. CAFs secrete a variety soluble factors that act in paracrine manner and thus affect not only cells, but also other cell types present the tumor stroma. Acting on promote growth invasion. They enhance angiogenesis by secreting activate endothelial cells pericytes. immunity is mediated via cytokines secreted immune CAFs. Both can exert tumor-suppressing -promoting effects. CAFs, they produce, are attractive targets therapy, have proven be useful prognostic markers. this review we focus mainly carcinomas discuss recent findings regarding role activated driving progression.