Neonatal exposure to androgens dynamically alters gut microbiota architecture.

摘要: Gonadal steroids strongly contribute to the metabolic programming that shapes susceptibility manifestation of diseases later in life, and effect is often sexually dimorphic. Microbiome signatures, together with traits sex steroid levels, were analyzed at adulthood neonatally androgenized female rats, compared those control male rats. Exposure rats high doses androgens on early postnatal life resulted persistent alterations profile namely lower progesterone higher estradiol estrone no endogenous androgens. Neonatally females heavier (10% 26% adulthood) than controls had impaired glucose homeostasis observed by AUC GTT ITT when subjected obesogenic manipulations. Androgenized displayed overt gut microbiota, indicated especially Bacteroidetes Firmicutes abundance adulthood, which disappeared animals concurrently overfed adulthood. Notably, these changes microbiota related intestinal expression several miRNAs, such as miR-27a-3p, miR-29a-5p, miR-100-3p. Our results suggest nutritional hormonal disruption developmental periods not only alters individual but also perturbs architecture may interact host a cross-talk mediated miRNAs; phenomena amplify derangement caused obesity, seen