MicroRNAs: Decoders of Dysbiosis into Metabolic Diseases?

摘要: The identification of molecular factors bridging gut microbiota dysbiosis to alterations host metabolism still remains a major goal in biomedical research. In fact, on one hand, there is worldwide consensus about the systemic impact, from brain liver, heart adipose tissue, dysbiosis. On other beyond microbial production short chain fatty acids and their vast metabolic properties, little known mechanisms linking change activity microbes modification cell metabolism. this context, microRNAs (also as miRs) are promising molecules which could allow explaining how converted into outcomes since: 1- miRs pleiotropic regulators gene expression, targeting multiple mRNAs at once; 2- expression specific organs such intestine has been demonstrated be under control microbiota; 3- have found majority tissues targeted by during diseases pancreas, skeletal muscle, intestine, also brain. review publications growing field miRs-based level will discussed together with putative link