Eosinophils may be involved in thrombus growth in acute coronary syndrome.

摘要: Thrombus aspiration therapy allows for the examination of thrombus and atheroma fragments in acute coronary syndrome (ACS). Inflammatory cells platelet activation play key roles formation ACS. However, histopathologic evaluation thrombi ACS has not been adequately addressed. We performed histologic analysis tissue samples obtained by therapy. studied 165 from patients with The area each sample, percentage red thrombus, white were measured. Samples stained immunohistochemically antibodies against macrophages, activated platelets, interleukin (IL)-5. Seventy-six included fragments. Macrophages, neutrophils, platelets observed Eosinophil infiltration was also predominantly between 106 samples. categorized all into 3 groups according to grade eosinophil (eos-, eos+, eos++ group). Sample group greater than that eos- (P < 0.0001). In addition, areas eos+ 0.009, P 0.02, respectively). there no difference groups. Staining IL-5 identified inflammatory within thrombi. Eosinophils may an important role occlusion promoting growth.