The expression of tumour suppressors and proto-oncogenes in tissues susceptible to their hereditary cancers

摘要: Studies of familial cancers have found that only a small subset tissues are affected by inherited mutations in given tumour suppressor gene (TSG) or proto-oncogene (POG), even though the mutation is present all tissues. Previous tests shown tissue specificity not due to presence vs absence expression, as TSGs and POGs expressed nearly every type normal human tissue. Using published microarray expression data we tested related hypothesis tissue-specific TSG POG highest where it oncogenic importance. We this examining whether individual had higher (noncancerous) they implicated relative those not. examined for 15 8 cancer across 12 types. significant difference between levels susceptible nonsusceptible It was 9 (60%, P<0.001) 5 (63%, their level effect. This highly association supports specific likely be most has its expression. suggests high potential marker linking cancer-related genes with